Question 1

What is Enclomiphene?

Accepted Answer

Enclomiphene is one of the two isomers that make up clomiphene citrate, used in men to raise the body's own testosterone production rather than replace it.

Clomiphene citrate is a blend of two geometric isomers: enclomiphene and zuclomiphene. Enclomiphene is the more anti-estrogenic component, and in men with secondary hypogonadism it has been studied for its ability to increase LH and FSH, which signals the testes to produce more testosterone. Zuclomiphene leans estrogenic (agonist-leaning) and stays in the body longer, which is why some clinician protocols prefer enclomiphene-only approaches.

Important distinction: while clomiphene citrate (the mixture) is FDA-approved for specific female fertility indications, enclomiphene by itself is not FDA-approved as a standalone drug.

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Kim ED, McCullough A, Kaminetsky J. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016;117(4):677-685. https://doi.org/10.1111/bju.13337

Earl JA, Kim ED. Enclomiphene citrate: a treatment that maintains fertility in men with secondary hypogonadism. Expert Rev Endocrinol Metab. 2019;14(3):157-165.

Question 2

Who is Enclomiphene for?

Accepted Answer

Enclomiphene is intended for men who want to boost their natural testosterone production while preserving fertility. It's particularly popular among younger men and those who prefer an oral medication over injections.

Question 3

How is Enclomiphene different from TRT?

Accepted Answer

Unlike traditional testosterone replacement therapy (TRT), which supplies external testosterone, Enclomiphene stimulates your body to produce more testosterone naturally, preserving fertility and testicular function.

Question 4

Will Enclomiphene preserve my fertility?

Accepted Answer

Enclomiphene works by prompting your own hormone production rather than replacing it, so sperm production continues.

Question 5

What are the side effects of Enclomiphene?

Accepted Answer

Side effects are typically mild and may include headache, nausea, visual disturbances, mood changes and hot flashes. They often subside as the body adjusts. Review Important Safety Information for full details.

Question 6

Does RespondWell require insurance?

Accepted Answer

No. We don't require insurance. You'll see clear pricing and can pay with HSA/FSA or credit/debit.

Question 7

How does RespondWell work?

Accepted Answer

Start with a quick health intake, connect with a licensed provider, and get personalized care – delivered to your door. RespondWell's care doesn't end when your medication arrives. Reach your care team 24/7 through secure messaging.

Question 8

How does my consultation work?

Accepted Answer

In most states your consultation is asynchronous — you complete a secure intake and a licensed clinician reviews it, typically in under 4 hours, with no live appointment required.

Here's how it works:

1. Complete your intake: Fill out a secure health questionnaire and add any questions or concerns.
2. Clinician review: A licensed provider reviews your intake, typically in under 4 hours.
3. Next steps: If everything is clear, and treatment is medically appropriate, your provider may issue a prescription. If more information is needed, your provider will message you with follow-up questions so you can respond on your schedule.

Some states require a live visit. If that applies to you, you'll choose a time and meet by phone or video:
Louisiana, Mississippi, Arkansas, Georgia, New Mexico, Tennessee, Virginia, West Virginia.

Testosterone Replacement Therapy (TRT): video consultations are required in all states.

You're not on your own after a prescription is issued. Message your provider via your patient portal anytime, or contact support via portal or text message.

Question 9

How does RespondWell handle billing and shipping?

Accepted Answer

Our plans are fully inclusive – your consultation, medication, injection supplies, and 2-day shipping are all covered, with no hidden membership fees.

When you start a consultation or order, a temporary authorization hold is placed on your card. If treatment isn't approved by your clinician, the hold is released or refunded promptly, though the exact timing depends on your bank. If labs were required prior to a denial, your refund will be issued minus the laboratory fees.

Once approved, your medication is shipped directly to you in discreet, temperature-controlled packaging (where required) via free expedited shipping. To ensure you never miss a dose, refills are processed automatically on 1-month and 3-month plans, but you're always in control – you can pause or cancel your subscription anytime through your portal. Pause/cancellation requests must be made prior to medication shipment.

Good to know: Because we work with a nationwide pharmacy network to ensure fast delivery, your actual packaging might look different than the images on our site.

Question 10

Does RespondWell use licensed pharmacies?

Accepted Answer

Yes, all medications are sourced through U.S.-based compounding pharmacies that follow strict regulatory and safety guidelines. You receive high-quality, pharmacy-grade treatments – always.

Question 11

Is RespondWell a pharmacy or manufacturer?

Accepted Answer

No. Your medication is dispensed and (if applicable) compounded by licensed pharmacies.

Question 12

Who are your pharmacy partners?

Accepted Answer

RespondWell works with a network of licensed pharmacy partners to fulfill prescriptions when approved by a licensed clinician. Pharmacy selection may vary by treatment, location, pharmacy licensing, and medication availability.

View our most updated pharmacy partner list here: Our Pharmacy Partners

Question 13

Who are your medical providers?

Accepted Answer

Independent clinical services are provided by:

Arora Health & Aesthetics
CMO Shannon Arora, MD
300 Lenora Street
Seattle, WA 98121
https://www.arora-health.com

Licensed in all 50 States + DC.

Question 14

Why do you need my credit card before my prescription is approved?

Accepted Answer

We collect your credit card as part of our secure checkout and identity verification process. Verifying that your card is active helps ensure that, if a licensed clinician approves your prescription, your order can be processed promptly and sent to the pharmacy without unnecessary delays.

At this stage, your card is not charged for the treatment. We only place a temporary authorization hold to confirm the card is active.

Question 15

What happens if my prescription is not approved?

Accepted Answer

If your prescription is not approved by the licensed clinician, your order will not move forward and the temporary authorization hold will be voided.

Our intake process screens for major disqualifying factors before you reach the thank-you page, so reaching that step generally means there is a reasonably high likelihood that you may be medically eligible for the treatment requested. Final eligibility, however, is always determined by the reviewing clinician.

If your prescription is approved, your card will be charged and your order will be sent to the pharmacy for fulfillment.

Question 16

Is RespondWell LegitScript Certified?

Accepted Answer

Yes. RespondWell is LegitScript certified — and so are our partner Medical Group and pharmacy partners. LegitScript is the gold standard for telehealth verification, and we cleared their review because we operate the right way: licensed providers, FDA-registered pharmacies, and zero shortcuts. If you've dealt with sketchy online "clinics" before, this is how you know we're not that.

Enclomiphene

How it works

Start from your phone

A clinician reviews your requested treatment

Your treatment ships

What Enclomiphene can do

Frequently asked questions

About Our Medications

Medical Consultation Required

Clinical References

Related treatments

Testosterone

Women's HRT

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